KONSTANTINOS AVGOUSTAKIS, PhD

PATRAS 2007 

PERSONAL DATA

SURNAME	:	AVGOUSTAKIS
NAME	:	KONSTANTINOS
DATE OF BIRTH	:	28/12/ 1961
PLACE OF BIRTH	:	IRAKLION, CRETE, GREECE
FAMILY STATUS	:	MARRIED, 2 children
JOB ADDRESS	:	PATRAS UNIVERSITY DEPARTMENT OF PHARMACY 265 00 RIO, PATRAS, GREECE
TELEPHONE / FAX	:	++2610-969330/ 2610-996302
e-mail/site	:	α This e-mail address is being protected from spambots. You need JavaScript enabled to view it /www. pharmacy.upatras.gr
RESIDENCE ADDRESS	:	KLADEOU 25, 26442 PATRAS, GREECE
TELEPHONE	:	++2610-435910

STUDIE

BACHELOR IN PHARMACY

ARISTOTLE UNIV. OF THESSALONIKI (1985), GREECE 

PhD DEGREE in QUALITY CONTROL

ARISTOTLE UNIV. OF THESSALONIKI (1991), GREECE

PhD in PHARMACEUTICAL TECHNOLOGY

KINGS COLLEGE LONDON, UNIVERSITY OF LONDON (1992), UK

CURRENT OCCUPATION

2008-

:

ASSOCIATE PROFESSOR, DEPARTMENT OF PHARMACY, UNIVERSITY OF PATRAS, GREECE

SOCIETIES MEMBERSHIP

- European Federation of Pharmaceutical Scientists (EUFEPS)

- CONTROLLED RELEASE SOCIETY

- GREEK PHARMACISTS ASSOCIATION (P.E.F)

FIELD OF EXPERTISE 

1. Pharmaceutical Technology

2. Development of controlled drug and vaccine delivery systems

3. Pharmaceutical Nanotechnology

REVIEWING:

1. Editorial Board Member for Current Nanoscience and Open Drug Delivery Journal (BENTHAM SCIENCE PUBL).

2. Reviewing for:

1. Journal of Controlled Release

2. Pharmaceutical Research

3. Journal of Pharmacy and Pharmacology

4. International Journal of Pharmaceutics

5. Current Nanoscience

6. Expert opinion on Drug Delivery

7. European Journal of Pharmaceutical Sciences

8. European Journal of Pharmaceutics and Biopharmaceutics

PUBLICATIONS

(1) Avgoustakis, K. and Nixon, J.R., Biodegradable controlled release tablets: 1. Preparative variables affecting the properties of poly(lactide-co-glycolide) copolymer as matrix forming material. Int. J. Pharm., 79 (1991) 77-85.

(2) Avgoustakis, K. and Niopas, I., “Dissolution and bioavailability evaluation of three brands of paracetamol tablets”. Epitheorese klinikes Farmacologias Farmakokinetikes, International Edition, 5 (1991) 58-61.

(3) Avgoustakis, K. , Athanasiou, A. and Georgakopoulos, P.P., “Effect of helix characteristics on the dissolution rate of hard gelatin capsules. Int. J. Pharm., 79 (1992) 67-69.

(4) Malamataris, S., Goidas, P. and Avgoustakis, K., “Comparative evaluation of soy polysaccharide as direct compression excipient”. Drug Dev. Ind. Pharm., 18 (1992) 1575-1587.

(5) Avgoustakis, K. and Nixon, J.R., Biodegradable controlled release tablets: II. Preparation and properties of poly(lactide-co-glycolide) powders. Int. J. Pharm., 99 (1993) 239-246.

(6) Avgoustakis, K. and Nixon, J.R., Biodegradable controlled release tablets: III. Effect of polymer characteristics on drug release from heterogeneous poly(lactide-co-glycolide) matrices. Int. J. Pharm., 99 (1993) 247-252.

(7) Panagi, Z., Sawas-Dimopoulou, C., Avgoustakis, K. and Ithakissios, D.S., Αpplication of ^99mTc-labeling for comparative screening of Preformed liposomes In Vivo. Drug. Dev. Ind. Pharm. 22 (1996) 217-224.

(8) Z. Panagi, K. Avgoustakis, G. Evangelatos and D.S. Ithakissios. Protein induced CF release kinetics from liposomes in vitro and its correlation with the BLOOD/RES biodistribution of liposomes. Int. J. Pharm., 163 (1998) 103-114.

(9) Z. Panagi, K. Avgoustakis, G. Evangelatos and D.S. Ithakissios. In vitro binding of HSA, IgG and HDL on liposomes and its correlation with the in vivo BLOOD/RES ratio of liposomes. Int. J. Pharm., 176(1999) 203-207.

(10) A. Beletsi, L. Leontiadis, P. Klepetsanis, D. S. Ithakissios and K. Avgoustakis. Effect of preparative variables on the properties of PLGA-mPEG copolymers related to their application in controlled drug delivery. Int. J. Pharm., 182(1999) 187-197.

(11) Z. Panagi., A. Beletsi, G. Evangelatos, E. Livaniou, D. S. Ithakissios, and K. Avgoustakis. Effect of dose on the biodistribution and pharmacokinetics of PLGA and PLGA-mPEG nanoparticles. Int. J. Pharm., 221(2001) 143-152. (AE: 18)

(12) V. Koutrafouri, L. Leondiadis, K. Avgoustakis, E. Livaniou, J. Czarnecki, D.S. Ithakissios and G.P. Evangelatos, Effect of thymosin peptides on the chick chorioallantoic membrane angiogenesis model, Biochim Biophys Acta, 1568(2001) 60-66.

(13) K. Avgoustakis, A. Beletsi, Z. Panagi, P. Klepetsanis, A.G. Karydas, and D.S. Ithakissios, PLGA-mPEG nanoparticles of cisplatin: in vitro nanoparticle degradation, in vitro drug release and in vivo drug residence in blood properties, J Control Release, 79(2002) 123-135. (IF (2002): 3.131)

(14) V. Koutrafouri, L. Leondiadis, N. Ferderigos, K. Avgoustakis, E. Livaniou, G. P. Evangelatos and D.S. Ithakissios, Synthesis and angiogenetic activity in the chick chorioallantoic membrane model of thymosin beta 15, Peptides 24 (2003) 107-115. (IF (2003): 2.440)

(15) K. Avgoustakis, A. Beletsi, Z. Panagi, P. Klepetsanis, E. Livaniou, G. Evangelatos and D. S. Ithakissios, Effect of copolymer composition on the physicochemical characteristics, in vitro stability, and biodistribution of PLGA–mPEG nanoparticles. Int. J. Pharm., 259 (2003) 115-127. (IF (2003): 1.539)

(16) N. Charalampopoulos, K. Avgoustakis, C. Kontoyannis, Differential pulse polarography: A suitable technique for monitoring drug release from polymeric nanoparticle dispersions. Analytica Chimica Acta, 491 (2003) 57-62. (IF (2003): 2.210)

(17) N. Stivaktakis, K. Nikou, Z. Panagi, A. Beletsi, L. Leondiadis, K. Avgoustakis, PLA and PLGA microspheres of β-galactosidase: Effect of formulation factors on protein antigenicity and immunogenicity, J. Biomed. Mater. Res. A., 70 (2004) 139-148. (IF (2004): 1.229)

(18) K. Avgoustakis, Pegylated Poly(Lactide) and Poly(lactide-co-glycolide) Nanoparticles: Preparation, Properties and Possible Applications in Drug Delivery, Current Drug Delivery, 1 (2004) 321-333.

(19) N. Stivaktakis, K. Nikou, Z. Panagi, A. Beletsi, L. Leondiadis, K. Avgoustakis, Immune responses in mice of β-galactosidase adsorbed or encapsulated in PLA and PLGA microspheres, J. Biomed. Mater. Res. A., 73 (2005) 332-338. (IF (2005): 2.743)

(20) A. Beletsi, Z. Panagi and K. Avgoustakis, “Biodistribution properties of nanoparticles based on mixtures of PLGA with PLGA–PEG diblock copolymers” Int. J. Pharm., 298 (2005) 233-241. (IF (2005): 2.156)

(21) E. Pierri, K. Avgoustakis, ‘Poly(lactide)-poly(ethylene glycol) micelles as a carrier for griseofulvin’, J. Biomed. Mater. Res. A., 75 (2005) 639-647. (IF (2005): 2.743))

(22) K. Nikou, N. Stivaktakis, K. Avgoustakis, P. A. Sotiropoulou, S. A. Perez, C.N. Baxevanis, M. Papamichail, L. Leondiadis, “A HER-2/neu peptide admixed with PLA microspheres induces a Th1 biased immune response in mice” Biochim Biophys Acta, 1725 (2005) 182-189. (IF (2005): 2.418)

(23) K. Avgoustakis, ‘Poly(lactic-co-glycolic acid)’, Encyclopedia of Biomaterials and Biomedical Engineering, G. Wnek and G. Bowlin Eds., Marcel Dekker, New York, 2005, Vol. 1, No1, p. 1 (invited contribution).

(24) G. Katsikogianni, K. Avgoustakis, ‘PLGA-mPEG nanoparticles: Drug loading and release properties’, J. Nanoscience Nanotechnology, 6 (2006) 3080-3086. (IF (2006): 2.194)

(25) E. C. Gryparis, G. Mattheolampakis, D. Bikiaris, K. Avgoustakis, “Effect of Conditions of Preparation on the Size and Encapsulation Properties of PLGA-mPEG Nanoparticles of Cisplatin” Drug Delivery, 14 (2007) 371-380.

(26) E. C. Gryparis, M. Hatziapostolou, E. Papadimitriou, K. Avgoustakis, “Anticancer activity of cisplatin-loaded PLGA-mPEG nanoparticles on LNCaP prostate cancer cells” Ε.J. Pharm. Biopharm., 67 (2007):1-8.

(27) E. Karavas, E. Georgarakis, M. P. Sigalas, V. I. Teberekidis, K. Avgoustakis, D. Bikiaris, “Investigation of the release mechanism of a sparingly water-soluble drug from solid dispersions in hydrophilic carriers based on physical state of drug, particle size distribution and drug-polymer interactions” Ε.J. Pharm. Biopharm., 66 (2007) 334-347.

(28) M. Efentakis, I. Pagoni, M. Vlachou, K. Avgoustakis, “Dimensional changes, gel layer evolution and drug release studies in hydrophilic matrices loaded with drugs of different solubility” Int. J. Pharm. 339 (2007) 66-75.

(29) Sofia Papadimitriou, Dimitrios Bikiaris, Konstantinos Avgoustakis. “Microwave-induced enhancement of dissolution rate of the poorly water-soluble Tibolone from solid dispersions” J. Appl. Polymer Sci., 108 (2008) 1249-1258.

(30) Sofia Papadimitriou, Dimitrios Bikiaris, Konstantinos Avgoustakis, Evangelos Karavas, Manolis Georgarakis, “Preparation and in vitro characterization of chitosan nanoparticles of dorzolamide and pramipexole”, Carbohydrate Polymers 73(2008) 44-54.

(31) A Beletsi, P. Klepetsanis, D.S. Ithakissios, S. Kounias, A. Stavropoulos and K. Avgoustakis, “Simultaneous optimization of cisplatin-loaded PLGA-mPEG nanoparticles with regard to their size and drug encapsulation”, Current Nanoscience 4 (2008) 173-178.

(32) George Mattheolabakis, George Lagoumintzis, Zoi Panagi, Sophia Kostara, Evangelia Papadimitriou, Charalambos D. Partidos, Konstantinos Avgoustakis, “Immune stimulation after transcutaneous delivery with antigen-loaded PLA nanoparticles”, (submitted)

(33) George Mattheolabakis, Zoi Panagi, Era Taoufik, Michael Roberts, Konstantinos Avgoustakis, “In vivo investigation of tolerance and antitumor activity of cisplatin-loaded PLGA-mPEG nanoparticles” (in print, Ε.J. Pharm. Biopharm.,)

(34) Dimitrios N. Bikiaris, George Z. Papageorgiou, Sofia A. Papadimitriou, Evangelos Karavas, Konstantinos Avgoustakis, Novel biodegradable polyester poly(propylene succinate): Synthesis and application in the preparation of solid dispersions and nanoparticles of a water soluble drug, AAPS PharmSciTech (accepted).

 

PATENTS

1. European Patent Application EP 1 698 327 A1 (2006) “Stable pharmaceutical compositions of itraconazole in aqueous environment” (Inventor K. Avgoustakis).

2. European Patent Application ΕΡΟ6386012 (2006) “Novel stable pharmaceutical compositions of risperidone in aqueous solution” (Inventor K. Avgoustakis).

PRESENTATIONS IN CONFERENCES

(1) Avgoustakis, K. and Georgakopoulos, P.P., “A study of possible improvements of USP XX dissolution test of hard gelatin capsules”. Proceedings of the 5th International Conference on Pharmaceutical Technology, APGI, Paris 1989, Vol. V, p. 460-468.

(2) Z. Panagi, C. Sawas-Dimopoulou, K. Avgoustakis, D.S. Ithakissios. A quick labelling method for evaluating liposomes with regard their biodistribution properties. World Congress of Pharmacy 1994, Lisbon, Portugal, 4-9 September, 1994. Abstracts Book of the 54th International Congress of FIP:146 (P175) (1994).

(3) Panagi, Z., Avgoustakis, K., Evangelatos, G. and Ithakissios, D.S., In vitro binding kinetics of serum proteins on selected liposomal types. Eur. J. Drug Metab. Pharmacokinet., Special Issue containing the abstracts of papers presented on 6th European Congress of Biopharmaceutics and Pharmacokinetics, Athens 1996.

(4) Panagi, Z., Avgoustakis, K., Evangelatos, G. and Ithakissios, D.S., Carboxyfluorescein leakage kinetics from liposomes due to liposome-protein interaction in vitro. Eur. J. Drug Metab. Pharmacokinet., Special Issue containing the abstracts of papers presented on 6th European Congress of Biopharmaceutics and Pharmacokinetics, Athens 1996.

(5) Panagi, Z., Avgoustakis, K., Evangelatos, G. and Ithakissios, D.S., Correlation of liposome-protein interaction in vitro with liposomes blood residence time in vivo. Eur. J. Drug Metab. Pharmacokinet., Special Issue containing the abstracts of papers presented on 6th European Congress of Biopharmaceutics and Pharmacokinetics, Athens 1996.

(6) Z. Panagi, K. Avgoustakis, G. Evangelatos and D.S. Ithakissios. In vitro interaction of liposomes with serum proteins and its correlation with the in vivo blood residence time of liposomes. Third European Congress of Pharmaceutical Sciences, Edinburgh, 15-17 September, 1996. Eur. J. Pharm. Sci. Vol. 4 Suppl.:S43 (1996).

(7) A. Beletsi, P. Klepetsanis, D. S. Ithakissios, S. Kounias, A. Stavropoulos and K. Avgoustakis. Optimized preparation of poly(lactide-co-glycolide)-poly(ethyleneglycol) nanoparticles loaded with cisplatin. Fourth European Congress of Pharmaceutical Sciences, Milan, 11-13 September, 1998. Eur. J. Pharm. Sci. Vol.6 Suppl.:S61 (1998).

(8) A. Beletsi, P. Klepetsanis, D. S. Ithakissios, S. Kounias, A. Stavropoulos and K. Avgoustakis. Biodegradable stealth nanoparticles loaded with cisplatin. (Abstracts Book) International scientific meeting on “Biodegradable micro/nano-particles and their applications in Medicine, Patras, 27-28 September, 1999.

(9) A. Beletsi, Z. Panagi, P. Klepetsanis, D. S. Ithakissios, L. Leondiadis, E. Livaniou, G. Evangelatos and K. Avgoustakis. PLGA-mPEG copolymers: Synthesis, characterization and application in the preparation of long circulating nanoparticles. (Abstracts Book) International scientific meeting on “Biodegradable micro/nano-particles and their applications in Medicine, Patras, 27-28 September, 1999.

(10) Z. Panagi, , A. Beletsi, G. Evangelatos, P. Klepetsanis D.S. Ithakissios, and K. Avgoustakis. Biodistribution of PLGA-mPEG nanoparticles: effect of copolymer composition. 27^th International Symposium on Controlled Release of Bioactive Materials, Paris, 7-13 July, 2000.

(11) V. Koutrafouri, L. Leondiadis, N. Ferderigos, K. Avgoustakis, E. Livaniou, G. P. Evangelatos and D.S. Ithakissios, Solid phase synthesis of thymosin beta-15 and investigation of its biological activity in the chorioallantoic membrane angiogenesis model. 26^th European Peptide Symposium, Montpellier, France, September 10-15, 2000.

(12) K. Avgoustakis, PLGAmPEG nanoparticles: preparation, characterization and application in controlled drug delivery. International Conference Particles 2002, Orlando, USA, 20-23- April 2002 (invited lecture).

(13) N. Charalambopoulos, A. Karatzikou, K. Avgoustakis, C. Kontoyannis. Study of drug release properties of PLGA-mPEG nanoparticles using differential pulse polarography. 30^th International Symposium on Controlled Release of Bioactive Materials, Glascow, 19-23 July, 2003.

(14) G. Katsikogianni, K. Avgoustakis. PLGA-mPEG nanoparticles: drug encapsulation and release properties. 30^th International Symposium on Controlled Release of Bioactive Materials, Glascow, 19-23 July, 2003.

(15) M. Effentakis, I. Pagoni, M. Vlachou, K. Avgoustakis. Effects of drug solubility on release and the dimensional changes utilizing image analysis. 30^th International Symposium on Controlled Release of Bioactive Materials, Glascow, 19-23 July, 2003.

(16) Georgios Blatsios, Achilleas Tzimas, Nikolaos Stivaktakis, Konstantinos Avgoustakis, Sotirios Gartaganis. Development of biodegradable microspheres for the transscleral controlled delivery of triamcinolone acetonide. Aegean Retina IX, 2005, Crete 1-3 July, 2005.

(17) Chrysovalantis E. Griparis, Mariza Hatziapostolou, Evangelia Papadimitriou, Konstantinos Avgoustakis. PLGA-mPEG Nanoparticles of Cisplatin: Anticancer Activity against LNCaP Prostate Cancer Cells. 33^rd Annual Meeting and Exposition of the Controlled Release Society, Vienna, Austria, 22-26 July, 2006.

(18) George Mattheolabakis, George Lagoumintzis, Zoi Panagi, Evangelia Papadimitriou, Konstantinos Avgoustakis, “Transcutaneous immunization with antigen-loaded PLA nanospheres” 34^th Annual Meeting and Exposition of the Controlled Release Society, Long Beach, USA, 7-11 July, 2007.

(19) K. Avgoustakis. Targeted delivery of cisplatin using polymeric nanoparticles. EHRLICH II, 2^nd World conference on magic bullets, Nurnberg, Germany, October 3-5, 2008